June 14, 2013
Today is KDd-1-9.
I received my 4th 37 mg dose of Kyprolis preceded by 4mg of dexamethasone and 250 mL of normal saline. Then a flush with about 10 mL of normal saline to make sure that I got all the Kyprolis.
5 hours later, I’m still feeling pretty good. The hiccups tried to start about 2 times today, but I managed to control the onset so that it went away.
I did pick up the results of the metabolic panel today and was glad to see that all was normal so that means no Tumor Lysis Syndrome (TLS), at least not yet.
Yesterday, I also picked up the results of my bone marrow biopsy and aspiration testing. These results show about 20% myeloma involvement now compared with about 40% when a sample was tested in April 2012. Warren advised that bone marrow is “lumpy” and these results may not be all that predictive. I’m still happy the number is lower.
A FISH (Fluorescence In-Situ Hybridization) cytogenetics panel was also run on the marrow sample. Basically, this checks for chromosome abnormalities, some of which point to more aggressive forms of myeloma. I was positive for: “Translocation t(11;14) is associated with cyclin D1 overexpression and is a favorable prognostic variable for newly diagnosed plasma cell myeloma patients treated with high-dose chemotherapy or autologous transplantation.” I am going to have to find out more about what this means, but I like the “favorable prognostic variable” part.
Thank you, Lord Jesus, for my healing.